0847 Real-World Idiopathic Hypersomnia Total Health Model (RHYTHM): Clinical Burden of Patients Diagnosed With Idiopathic Hypersomnia

Abstract Introduction Idiopathic hypersomnia (IH) is a rare neurologic disorder that can cause debilitating symptoms, including excessive daytime sleepiness, severe sleep inertia, prolonged nighttime sleep, long and unrefreshing naps, cognitive dysfunction. Limited research has investigated the clinical burden associated with IH. This study compared profile of patients diagnosed IH versus matched non-IH controls. Methods MarketScan® administrative claims were analyzed between December 2013 February 2020. Eligible aged ≥18 years upon cohort entry had 365 days continuous medical coverage (gaps ≤30 allowed) before after entry. cases entered first claim containing an diagnosis without history cataplexy. Non-IH controls 5:1 to on age, sex, region, payer type, date. Prevalence estimates Clinical Classification System Multilevel (CCSM) categories comorbid conditions during 2-year period cohorts using logistic regression. Odds ratios (ORs) 95% confidence intervals (CIs) reported. Results The final included 11,428 57,138 controls, respectively. Approximately two-thirds sample was female (65.0%); median age 45 years. Compared experienced significantly higher prevalence all CCSM categories. disorders, such as apnea (OR: 26.1 [CI: 24.8, 27.6]), mood disorders 3.7 3.6, 3.9]), headache/migraine 2.9 2.7, 3.0]), among Similarly, cardiovascular conditions, disease 2.2 2.1, 2.4]), stroke 2.0, major adverse events composite hypertension or use antihypertensive medications 2.0 2.1]), heart failure 1.8, 2.3]), more prevalent Conclusion Patients experience significant psychiatric comorbidities, acute chronic illnesses. consistent observations in other namely, narcolepsy. Holistic treatment strategies for are needed, requiring careful consideration patients’ overall when selecting therapies. Support (if any) Jazz Pharmaceuticals.